Faecal Occult Blood Test

Case of the Month (Emma Scurrell May 2011)

Hepatic amyloidosis in a cat 

A 2-year-old Siamese cat presented with a fatal abdominal haemorrhage. On post-mortem examination, the liver was swollen and contained multiple areas of intrahepatic and capsular haemorrhage. Samples of liver were submitted for histopathology.

 Fig 1. H&E section of the liver in which the perisinusoidal spaces are infiltrated and replaced by variable quantities of a pale eosinophilic, amorphous acellular matrix (black arrows) typical of amyloid.

Fig 2. Congo red stain which is used to confirm the presence of amyloid. Amyloid stains an orange-red with Congo-red stain (black arrows) and displays apple-green birefringence under polarised light


Final Diagnosis

Hepatic amyloidosis


Amyloid accumulation within the liver of cats is sporadic and can occur as a primary/familial disease or secondary to chronic inflammatory disease. Affected livers are prone to rupture resulting in haemorrhage which can be fatal. Familial hepatic amyloidosis is known to occur in Abyssinians but is also suspected in Siamese and Oriental breeds. Interestingly, one of the littermates of this young cat was subsequently diagnosed with hepatic amyloidosis consistent with a familial aetiology. 

Previous Monthly Cases

Hypertensive Retinopathy January 2010
FIP in a cat - uncommon presentation February 2010
Phaeohyphomycosis    March 2010 
Scleral Rupture April 2010
Canine and feline epulides May 2010
Erythema multiforme in a labrador retreiver June 2010
Keloidal fibrosarcoma in a labrador retreiver July 2010
Cutaneous epitheliotropic lymphoma  August 2010 
Benign cutaneous histiocytoma  September 2010 
Iridociliary adenoma October 2010
Proliferative thrombovascular necrosis of the pinnae November 2010
Signet-ring cell carcinoma in the stomach of a dog December 2010
Cutaneous infiltrative lipoma in a labrador January 2011

Tonsillar squamous cell carcinoma February 2011
Canine orbital meningioma March 2011
"Lung-digit" syndrome in a cat April 2011

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Faecal Occult Blood Test