Faecal Occult Blood Test

Case of the Month (Emma Scurrell August 2011)

Ocular manifestation of lymphoma in a cat 

 A 12-year-old male DSH cat presented with bilateral uveitis and diffuse thickening of the iris associated with a shallow anterior chamber. Below are images from the aqueocentesis sample (fig.1) and subsequent gross and histopathological specimens (figs.2&3) from one of the enucleated globes


 Fig 1. In this cytology prep, there are low numbers of large neoplastic lymphocytes. Compare the size of the lymphocytes (specifically their nuclei) to that of the surrounding red blood cells to assess the cell size more objectively. To give you a better idea of cell size, the size of the nucleus in a small lymphocyte approximates that of a red blood cell.  


Fig 2. This is a gross specimen of the enucleated globe. The iris and ciliary body are diffusely thickened and discoloured white. Note the associated shallowing of the anterior chamber. 

 

Fig 3. H&E section revealing sheets of densely-packed large neoplastic lymphocytes. Mitotic figures were frequent (not shown in this image).





Final Diagnosis

Uveal lymphoma (large cell, high grade)

Discussion

Cases of large cell/high grade lymphoma affecting the eye in both dogs and cats should be viewed as a multisystemic disease process even if the initial clinical manifestation appears to be restricted to the eye(s). Aqueocentesis can be used as a diagnostic tool in an attempt to confirm the diagnosis and is probably most useful when lymphoma is suspected. Enucleation can also be used to confirm the diagnosis in an irreversibly blind eye but should not be viewed as a curative procedure in the majority of cases.

Previous Monthly Cases

Hypertensive Retinopathy January 2010
FIP in a cat - uncommon presentation February 2010
Phaeohyphomycosis    March 2010 
Scleral Rupture April 2010
Canine and feline epulides May 2010
Erythema multiforme in a labrador retreiver June 2010
Keloidal fibrosarcoma in a labrador retreiver July 2010
Cutaneous epitheliotropic lymphoma  August 2010 
Benign cutaneous histiocytoma  September 2010 
Iridociliary adenoma October 2010
Proliferative thrombovascular necrosis of the pinnae November 2010
Signet-ring cell carcinoma in the stomach of a dog December 2010
Cutaneous infiltrative lipoma in a labrador January 2011

Tonsillar squamous cell carcinoma February 2011
Canine orbital meningioma March 2011
"Lung-digit" syndrome in a cat April 2011
Hepatic amyloidosis in a cat May 2011
Haemophagocytic histiocytic sarcoma June 2011
Alternaria spp. infection in an immunocompromised dog July 2011



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Faecal Occult Blood Test