Faecal Occult Blood Test

Case of the Month (Emma Scurrell March 2013)

Splenic mast cell tumour in a cat

A blood sample was submitted for routine haematology from a seven-year-old female DSH with a history of marked splenomegaly. A fine needle aspirate of the enlarged spleen was performed and subsequently, the spleen was removed and submitted for histopathology.



Fig 1.  Blood smear: there are rare, well-granulated mast cells in the feather-edge (arrow).


Fig 2.  A fine needle aspirate from the spleen reveals large numbers of well-granulated and moderately pleomorphic mast cells.

 

Fig 3.  An H&E section taken from the diffusely enlarged spleen similarly reveals effacement of the splenic tissue by densely-packed sheets of mast cells. Granulation is not as obvious in this section compared to the cytology.   







Final Diagnosis

Splenic mast cell tumour associated with mastocytaemia (systemic mastocytosis)

Discussion

Unlike in dogs, circulating mast cells in cats are not typically associated with non-neoplastic disease and their presence should raise the suspicion of so-called visceral/systemic mastocytosis or a mast cell tumour, particularly splenic. The mastocytaemia in this cat persists following splenectomy.

Previous Monthly Cases

Hypertensive Retinopathy January 2010
FIP in a cat - uncommon presentation February 2010
Phaeohyphomycosis    March 2010 
Scleral Rupture April 2010
Canine and feline epulides May 2010
Erythema multiforme in a labrador retreiver June 2010
Keloidal fibrosarcoma in a labrador retreiver July 2010
Cutaneous epitheliotropic lymphoma  August 2010 
Benign cutaneous histiocytoma  September 2010 
Iridociliary adenoma October 2010
Proliferative thrombovascular necrosis of the pinnae November 2010
Signet-ring cell carcinoma in the stomach of a dog December 2010
Cutaneous infiltrative lipoma in a labrador January 2011

Tonsillar squamous cell carcinoma February 2011
Canine orbital meningioma March 2011
"Lung-digit" syndrome in a cat April 2011
Hepatic amyloidosis in a cat May 2011
Haemophagocytic histiocytic sarcoma June 2011
Alternaria spp. infection in an immunocompromised dog July 2011
Ocular manifestation of lymphoma in a cat  August 2011
Kerion dermatophytosis in a Cocker spaniel September 2011
Subcuticular coenurus in a rabbit  October 2011
Optic nerve glioma in a dog November 2011
Malignant transformation of a viral papilloma in a dog  December 2011
Uveodermatological syndrome in an Akita
January 2012
Cutaneous angiostomatosis in a dog  February 2012
Transitional cell carcinoma in a dog  March 2012
Corneal inclusion cysts in a dog   April 2012
Extraskeletal osteosarcoma in a dog  May 2012
Subungual melanoma in a dog  June 2012
Retrobulbar grass seed in a dog   July 2012
Lungworm infection associated with hypercalcaemia in a dog  August 2012
Conjunctival melanoma in a dog  September 2012
Pneumocystis infection in a Cavalier King Charles Spaniel  October 2012
Fungal keratitis and secondary endophthalmitis in a horse November 2012
Myeloid leukaemia with lymph node invasion in a dog    December 2012
Cutaneous toxoplasmosis in a cat   January 2013
Glomerulonephritis in a dog  February 2013



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Faecal Occult Blood Test