Faecal Occult Blood Test

Case of the Month (Emma Scurrell January 2014)

Urticarial allergic reaction in a dog

This is a skin biopsy from a 3-year-old Jack Russell Terrier. The dog developed a generalised erythematous rash and limb oedema within 36 hours of antibiotic and anti-inflammatory treatment for a bout of vomiting and diarrhoea. 


Fig 1.  In sections of haired skin, the epidermis is intact and the superficial perivascular to interstitial dermis contains a multifocal, moderate cellular infiltrate (arrows) accompanied by mild dermal oedema.
 








Fig 2.  The cellular infiltrate is dominated by eosinophils (arrow). The endothelium lining the dermal blood vessels (bv) is consistently plump.
 

 




Final Diagnosis

Superficial perivascular to interstitial eosinophilic dermatitis

Discussion

The histopathology together with the clinical history is consistent with urticarial allergic eruption, associated with a hypersensitivity reaction. It is not cause-specific but an adverse drug reaction is one of the most commonly reported causes and was suspected in this particular case. Other causes include insect/arthropod bites, vaccines and food allergy.

Previous Monthly Cases

Hypertensive Retinopathy January 2010
FIP in a cat - uncommon presentation February 2010
Phaeohyphomycosis    March 2010 
Scleral Rupture April 2010
Canine and feline epulides May 2010
Erythema multiforme in a labrador retreiver June 2010
Keloidal fibrosarcoma in a labrador retreiver July 2010
Cutaneous epitheliotropic lymphoma  August 2010 
Benign cutaneous histiocytoma  September 2010 
Iridociliary adenoma October 2010
Proliferative thrombovascular necrosis of the pinnae November 2010
Signet-ring cell carcinoma in the stomach of a dog December 2010
Cutaneous infiltrative lipoma in a labrador January 2011

Tonsillar squamous cell carcinoma February 2011
Canine orbital meningioma March 2011
"Lung-digit" syndrome in a cat April 2011
Hepatic amyloidosis in a cat May 2011
Haemophagocytic histiocytic sarcoma June 2011
Alternaria spp. infection in an immunocompromised dog July 2011
Ocular manifestation of lymphoma in a cat  August 2011
Kerion dermatophytosis in a Cocker spaniel September 2011
Subcuticular coenurus in a rabbit  October 2011
Optic nerve glioma in a dog November 2011
Malignant transformation of a viral papilloma in a dog  December 2011
Uveodermatological syndrome in an Akita
January 2012
Cutaneous angiostomatosis in a dog  February 2012
Transitional cell carcinoma in a dog  March 2012
Corneal inclusion cysts in a dog   April 2012
Extraskeletal osteosarcoma in a dog  May 2012
Subungual melanoma in a dog  June 2012
Retrobulbar grass seed in a dog   July 2012
Lungworm infection associated with hypercalcaemia in a dog  August 2012
Conjunctival melanoma in a dog  September 2012
Pneumocystis infection in a Cavalier King Charles Spaniel  October 2012
Fungal keratitis and secondary endophthalmitis in a horse November 2012
Myeloid leukaemia with lymph node invasion in a dog    December 2012
Cutaneous toxoplasmosis in a cat   January 2013
Glomerulonephritis in a dog  February 2013
Splenic mast cell tumour in a cat  March 2013
Laryngeal rhabdomyoma in a dog  April 2013
Mycobacterial infection in an eye May 2013
Key Gaskell syndrome in a cat June 2013
Intraosseous epidermoid cyst in the toe of a dog July 2013
Septic Lens Implantation Syndrome August 2013
Fungal Keratitis in a dog September 2013
Fatal Cowpox Infection in a Cat
October 2013
Lingual granular cell tumour in a dog November 2013
Leydig cell tumour in a dog December 2013



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Faecal Occult Blood Test