Faecal Occult Blood Test

Case of the Month (Emma Scurrell August 2015)

Myelofibrosis in a dog with non-regenerative anaemia

A 7-year-old Cocker Spaniel presented for lethary caused by a chronic non-regenerative anaemia (Ht - 12%)


Fig 1. On examination of a blood smear, various RBC morphology changes are present but the predominant finding is a large number of elliptocytes (ovalocytes).




Fig 2. The bone marrow aspirate is paucicellular. A bone marrow core biopsy reveals myelofibrosis whereby the haematopoietic tissue is largely replaced by fibrous tissue.

 

Fig 3. A closer look at the mature fibrous tissue that lines the trabecular and replaces the bone marrow. 

 





Final Diagnosis

Myelofibrosis associated with a marked, non-regenerative anaemia

 Discussion

The RBC morphology seen in the blood smear (+++ ovalocytes) is not specific but it does suggest bone marrow disease (e.g. myelofibrosis or myelodysplastic disease/myeloid neoplasia. The myelofibrosis confirmed on histopathological examination of a bone marrow core accounts for the chronic marked non-regenerative anaemia in this case. This condition can be idiopathic but known causes of myelofibrosis include chronic bleeding, neoplasia, chronic inflammation, the use of myelotoxic drugs including cyclophosphamide and oestrogens and radiation treatment. 


Previous Monthly Cases

Hypertensive Retinopathy January 2010
FIP in a cat - uncommon presentation February 2010
Phaeohyphomycosis    March 2010 
Scleral Rupture April 2010
Canine and feline epulides May 2010
Erythema multiforme in a labrador retreiver June 2010
Keloidal fibrosarcoma in a labrador retreiver July 2010
Cutaneous epitheliotropic lymphoma  August 2010 
Benign cutaneous histiocytoma  September 2010 
Iridociliary adenoma October 2010
Proliferative thrombovascular necrosis of the pinnae November 2010
Signet-ring cell carcinoma in the stomach of a dog December 2010
Cutaneous infiltrative lipoma in a labrador January 2011

Tonsillar squamous cell carcinoma February 2011
Canine orbital meningioma March 2011
"Lung-digit" syndrome in a cat April 2011
Hepatic amyloidosis in a cat May 2011
Haemophagocytic histiocytic sarcoma June 2011
Alternaria spp. infection in an immunocompromised dog July 2011
Ocular manifestation of lymphoma in a cat  August 2011
Kerion dermatophytosis in a Cocker spaniel September 2011
Subcuticular coenurus in a rabbit  October 2011
Optic nerve glioma in a dog November 2011
Malignant transformation of a viral papilloma in a dog  December 2011
Uveodermatological syndrome in an Akita
January 2012
Cutaneous angiostomatosis in a dog  February 2012
Transitional cell carcinoma in a dog  March 2012
Corneal inclusion cysts in a dog   April 2012
Extraskeletal osteosarcoma in a dog  May 2012
Subungual melanoma in a dog  June 2012
Retrobulbar grass seed in a dog   July 2012
Lungworm infection associated with hypercalcaemia in a dog  August 2012
Conjunctival melanoma in a dog  September 2012
Pneumocystis infection in a Cavalier King Charles Spaniel  October 2012
Fungal keratitis and secondary endophthalmitis in a horse November 2012
Myeloid leukaemia with lymph node invasion in a dog    December 2012
Cutaneous toxoplasmosis in a cat   January 2013
Glomerulonephritis in a dog  February 2013
Splenic mast cell tumour in a cat  March 2013
Laryngeal rhabdomyoma in a dog  April 2013
Mycobacterial infection in an eye May 2013
Key Gaskell syndrome in a cat June 2013
Intraosseous epidermoid cyst in the toe of a dog July 2013
Septic Lens Implantation Syndrome August 2013
Fungal Keratitis in a dog September 2013
Fatal Cowpox Infection in a Cat
October 2013
Lingual granular cell tumour in a dog November 2013
Leydig cell tumour in a dog December 2013
Urticarial allergic reaction in a dog January 2014
Conjunctival foreign body in a dog  February 2014
An enlarged sublumbar lymph node in a hypercalcaemic dog  March 2014
Perineural invasion of a carcinoma in a dog  April 2014
Intestinal pseudo-obstruction in a dog  May 2014
Sebaceous adenitis in a dog  June 2014
Ovarian teratoma  July 2014
Cutaneous cowpox virus infection in a cat  August 2014
Acute renal falure in a cat  September 2014
Azothioprine toxicity in a dog  October 2014
Neoplastic pleural effusion in a dog November 2014
Squamous cell carcinoma in the orbit of a dog December 2014
Feline lungworm January 2015
Cutaneous haemangiosarcoma in an elderly dog February 2015
Ductal plate malformation  March 2015
Hodkin's-like lymphoma in a cat  April 2015
Interstitial (Leydig) cell tumour in a cat May 2015
Sialocoele in a dog June 2015
Bilateral ovotestes in a dog July 2015



CytoPath Ltd | PO Box 24 | Ledbury | Herefordshire | HR8 2YD |
tel: 01531 63 00 63 | fax: 01531 63 00 33 | email: customer.enquiries@cytopath.co.uk | web: www.cytopath.co.uk

2009 Cytopath Limited / / all rights reserved / / design and development by mightyweb.co.uk

Faecal Occult Blood Test